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Human ageing

Cross-linking theory of aging

Old couples Image credit goes to pixabay.com Cellinsight Everything about human ageing and related diseases Cross-linking theory The cross-linking theory of aging was proposed in 1942 by Johan Bjorksten. According to this theory Collagen and other proteins undergoing structural changes due to molecular cross linkage (collagen is an important body proteins comprising 30℅ of body proteins) . In the presence of oxygen glucose molecules binding to to proteins and this cross-linked proteins causing damage to cells and tissues resulting in aging. This theory is also called as glycosylation theory of aging.  # Wrinkle and skin changes The cross-linked skin protein collagen  is responsible for wrinkles and skin changes during aging # Tendon stiffening An increased cross-linked collagen is the reason behind tendon stiffening, tendons are connective tissues which connect muscles to bones. a stiff tendon can pass more mechanical energy from muscles to bone but it lose it's elastic prop
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WHAT IS CORONA VIRUS?


Corona virus
Corona virus

Dear friends ,today the world is under a dangerous pandemic the COVID-19 so-many people dying word wide,so I think it is necessary to write on corona virus,how ever our regular subject remain 'human aging'
Before going the details of corona virus we should know what is viruses,

How pandemic is differ from epidemic?

 Epidemic is a disease that effects a large number of people in a region where as  a Pandemic is an infectious disease that has the ability to spread across continents or even the entire world.

What is virus?

In1886 Adolf mayor,a German agricultural chemist who first described about a disease,the tobacco mosaic disease,mosaic like appearance on leafs of tobacco plant.later Martinus Beijerich given the name Virus,Virus is a latin word,means a poisonous subsance                                       
Viruses are generally considered as non living things, but they active when enter a host cell.they consist of genetical codes(the RNA or DNA)body is covered  by a protein coat,which is known as. Capsids,in some virus especially in the case of novel corona virus the capsid is covered by two layers of lipids,which is known as envelop.viruses cannot multiply themself,they must enter living cell. When they Come out from a living cell they become inactive,this inactive virus is called as virion,this is responsible for infection.if it did n't get a host cell in certain time period the lipid coating and capsid begins to degrade,then it cannot attach to the host cell

Which are the corona viruses that attacked human?

Corona virus SARS-CoV(sever acute syndrome) is identified in southern China in 2003,MERS-CoV(Middle East respiratory syndrome)identified in Soudi Arabia in 2012,and this is the third one SARS-CoV2,the causativ agent of  the deseas COVID-19 and this virus also fist identified in China in 2019.

How long survive corona virus outside the host cell?

Novel corona virus can survive3 days on stainless steel surfaces and plastic surfaces,it can live on air for hours,one day on card boards and four hour on copper.the virus survive longer time at lower temperature,higher humidity and non porous surfaces like stainless steel.


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