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Neuro endocrine theory(biological clock) of aging

NEURO ENDOCRINE THEORY OF AGING  According to Neuro endocrine theory the aging process is happening in hypothalamus,pituitary,and thyroid or the in regulatory action of these glands.Vladimer Dilman an internationally renowned endocrinologist put forward this theory in 1968.He found that there is considerable decline in the production of hormones in our body with increasing age,the secretion of thyroid,adrenel cortex,testis (males),ovary (females),pituitary (growth hormone) etc will falls.The production of aminoacids, peptides,monoamines enzymes etc also will decrease.it is also noted that the functional decline in neurons, Human endocrine system What are the functions of endocrine glands? Endocrine system is a group of glands,which produce most of all important hormones for our body.These hormones controls our growth development,moods,metabolism,reproduction etc. The glands includes Hypothalamus,pituitary,pineal(these3glands situated in brain),thyroid(ne...
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Genome Editing Technologies

style="text-align: left;"> Genome Editing: A Comprehensive Guide Genome-editing Recently Genome editing has seen remarkable advancement in the field of medicine, agriculture and biotechnology. Genome editing started in 1990s.There are many Platforms available for genetical editing, they are ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), Meganucleases, CRISPR/ Cas systems etc. Cas systems is more efficient and convenient compared to other platforms.  1.CRISPR-Cas Systems.  CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas systems are famous for it's simplicity and efficiency, they are widely used for Gene-editing in recent years. When a bacterium infected by bacteriophage- virus, bacterial immune system, that's Crispr-Cas systems protect them. Crispr-Cas9 system found in streptococcus pyogenes , when virus attack this bacteria the Cas9- system detect it and bacteria produced a guide RNA ( ...
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Cross-linking theory of aging

Structural changes of proteins due to molecular Cross-linking Cellinsight Everything about human ageing and related diseases Understanding Cross-linking theory The cross-linking theory of aging was proposed in 1942 by Johan Bjorksten. According to this theory Collagen and other proteins undergoing structural changes due to molecular cross linkage (collagen is an important body proteins comprising 30℅ of body proteins) . In the presence of oxygen glucose molecules binding to to proteins and this cross-linked proteins causing damage to cells and tissues resulting in aging. This theory is also called as glycosylation theory of aging.  # Wrinkle and skin changes The cross-linked skin protein collagen  is responsible for wrinkles and skin changes during aging # Tendon stiffening An increased cross-linked collagen is the reason behind tendon stiffening, tendons are connective tissues which connect muscles to bones. a stiff tendon can pass more mechanical energy from ...
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