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Showing posts from May, 2020

Human ageing

Effects of enzymes on aging and related diseases .

Effects of enzymes on aging and related diseases  Enzymes How enzyme catalyze a chemical reaction Enzymes are biological catalysts , catalysts are those substances which can alter the speed of chemical reactions.There are positive and negative catalysts, positive catalysts speed up chemical reactions where as negative catalysts decreases the rate of chemical reactions.Enzymes are positive catalysts, which accelerate chemical reactions in our body.Enzymes are basically proteins ,made up of long chains of amino acids .Enzymes are discovered in 1897 by a German biochemist Eduard Buchner , he got Nobel prize in chemistry in 1907 for his discovery of cell-free fermentation . He showed that an enzyme named zymase extracted from yeast cells can break up sugar into alcohol and carbon dioxide.There are about 40,000 different enzymes present in our body ( these number may increase because every day new enzymes are discovering )each enzyme catalyze a different chemical r

The free radical theory of aging

The free radical theory of aging Dr.Denham Herman a scientific researcher who proposed the ' free radical theory of aging ' in the year 1956.according to this theory the process of aging is due to oxidative damage of cell organelles and other cytoplasmic contents by free radicals. intially it was assumed that the free radicals such as ROS(reactive oxygen species) produced during normal respiratory process.The free radical theory got more attention when researchers studied the cause of cancer ,Alzheimer disease,and heart diseases .This theory realises that old age is just another disease,our old age is starting when mitochondrial DNA (mtDNA) get damaged by free radicals. 1970s many scientist involved in Reserch related to this theory and in 1980 J.Miquel clearly explained the mitochondrial involvement in the  production of free radicals,the theory is known as mitochondrial theory of free radicals. Cell structure                    Animal cell,inrenal view (mitocho