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Role of protein on ageing


Role of protein on ageing
Protein structure 



Role of protein on aging 

Protein which controls the length of telomere are telomerase and a protein complex known as shelterin.a new study by Scripps Reserch Institute (TSRI) discovered a new protein named as TZAP (telomeric zinc associated protein)which decrease the length of telomeres by trimming,telomere is the clock of a biological cell,if it's length is too short the cell cannot multiply,a human cell can divide maximum 50 times,if it increase more, our life span may increase considerably.
Certain proteins undergo oxidisation which are known to be associated with ageing and some age related diseases,when people turn about 80 approximately half of the bady proteins are damaged due to oxidation,the oxidation occurs because of random chemical degradation,that are associated with convention of food particles to enregy( metabolism) .
Protein's misfoldings are another reason for ageing,when native proteins are synthesised in our cells,which is in helical(Alfa helical)structure and everything fine,but in some cases the proteins produced are misfolded and which are considered as minimum energy state proteins,these proteins are useless or even toxic.these proteins are insoluble in water,where as good proteins are soluble,these misfolded proteins later form a long lenear aggregate known as amyloid diposit,these deposit causes diseases also,for examble Alzheimer's disease.

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The answer is simple,the 'errors'.The errors that happening during cell multiplication and by the influences of external factors.So Many changes happens in DNA every year,most important one is the shortening of telomeres.A telomere is the tail end of chromasome.The free radical theory of -ageing, which devolved in1950 says that the reactive oxygen species(ROS)  produced during mitochondrial functions react with their DNA (mtDNA)  and other cell organelles, makes sever damage and declined mitochondrial functions that leads us to aging.ROS is produced when mitochondria make energy from food particles,when we eat more the mitochondria produce more energy and more ROS also evolved as by product.So having a comparatively limited amount of diet may be better to increase life span
In the year 1961 an American scientist L.Hayflick discovered that human cells have limited capacity to divide.Human cells are not able to divide again after 50 cell divisions,this cond…