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Role of protein on ageing


Role of protein on ageing
Protein structure 



Role of protein on aging 

Protein which controls the length of telomere are telomerase and a protein complex known as shelterin.a new study by Scripps Reserch Institute (TSRI) discovered a new protein named as TZAP (telomeric zinc associated protein)which decrease the length of telomeres by trimming,telomere is the clock of a biological cell,if it's length is too short the cell cannot multiply,a human cell can divide maximum 50 times,if it increase more, our life span may increase considerably.
Certain proteins undergo oxidisation which are known to be associated with ageing and some age related diseases,when people turn about 80 approximately half of the bady proteins are damaged due to oxidation,the oxidation occurs because of random chemical degradation,that are associated with convention of food particles to enregy( metabolism) .
Protein's misfoldings are another reason for ageing,when native proteins are synthesised in our cells,which is in helical(Alfa helical)structure and everything fine,but in some cases the proteins produced are misfolded and which are considered as minimum energy state proteins,these proteins are useless or even toxic.these proteins are insoluble in water,where as good proteins are soluble,these misfolded proteins later form a long lenear aggregate known as amyloid diposit,these deposit causes diseases also,for examble Alzheimer's disease.

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In 1961 an american scientist L.Hayflick discovered that human cells have limited capacity to divided,after 50 cell divions the cell not able to divide again,this limit is called Hayflck limit,the cell gradually lose its efficiency and is said …