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Why we are getting old?

How we are getting old?

The answer is simple,the 'errors'.the  errors that happening during cell multiplicaton and by the influences of external factors.so many changes happens in DNA every year,most important one is the shortening of telomers,a telomere is the tail end of chromosome  The free radical theory of aging,which developed in 1950s,says that the reactive oxygen species (ROS) produced during mitochondrial function react with their DNA(mtDNA) and other cell organalls make sever cdamage and decline in mitochondrial function that leads to aging,ROS is produced when mitochondria makes energy,when you eat more the mitochondria produce more energy at the same time more ROS also produce,so eating less can increase life span to an extent.

In 1961 an american scientist L.Hayflick discovered that human cells have limited capacity to divided,after 50 cell divions the cell not able to divide again,this limit is called Hayflck limit,the cell gradually lose its efficiency and is said to be aged.Later A.M Olovnikov proposed the Telomere theory of aging,telomers are the the end segments of chromosome,which protect chromasome,the theory says after each cell divition the length of telomers become shorter and shorter,when it is too short cell can not divide.when we born the length of telomers in our white blood cells (W.B.C) is 800 base pairs but when we become elder the length will bev 1500 base pairs only.


According to neuro endocrine theory age changes happend in hypothalamus,pituitary,and thyroid glands or by the combined action of these glands.Aging associated with the decreased production of certain hormones and also the functional decline of neurons.



Our cells also subjects to DNA mythilation,this involve adding a methyl group(a carbon and 3 hydrogen atoms),to the area of DNA which sets this area of gene in to off mode,then the particular function will not work,if we examin how much DNA is methylated then we can estimate their biological age,some genes may also hypermethylated with age causing them to loose some functions such as estrogen receptor another reason is the environmental damage to DNA,proteins and fats,after the age of 20 humans produce 1% less collagen in the skin each year,result in skin becoming more and more brittle.80% of skin wrinkling happens because of UV radiation from sunlight.

In the case of a well known human disease called Werner's Syndrome,a mutated gene cause people older in their teen age,the mutated gene supposed to be involved in DNA maintain function,so we have to focus on DNA repair related gene,mRNA,proteins  Dear friends, these are some of the reasons that scientists explained but exact reason not yet known ,you give me whatever you know about it plz,l need a lot of information from the entire world in this regard                                     

         
Why we are getting old?

Old-age

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